Abstract

Objective: The research and development of potent bi oactive components with pharmacological properties has received much attention in the recent years. So, the anti inflammatory, analgesic and gastroprotective activities of the organic extract and its polar fractions (F2 and F3) from the Mediterranean white gorgonian Eunicella si ngularis were investigated. Methods: Anti-inflammatory and analgesic activities were evaluated, using the carrageenan-induced rat paw edema model and the acetic acid writhing test in mice. The gastroprotective activity was determined using HCl/EtOH induced gastric ulcers in rats. Results: The organic extract exhibited interesting anti inflammatory, analgesic and gastroprotective activities in a dose dependent manner. Similarly the fractions F2 and F3 showed, respectively, an interesti ng anti inflammatory activity associated with significant analg esic and gastroprotective activities, efficacies that corr elated with their bioactive components and total phenol content. Conclusions: Our findings confirmed that the anti inflammatory, analgesic and gastroprotective activities of Eunicella singularis organic extract and its polar fra ctions could be correlated with their bioactive components and total phenol content.