Abstract

Objective: In the present study, the effect of selenium nanoparticles (SeNPs) and ferulic acid (FA) on acrylamide (AC) induced neurotoxicity in rats was investigated. Methods: Sixty adult male rat s were divided equally into six groups and orally treated as follows: Group I (control): 1ml per day physiological saline; group II (SeNPs): 0.5 mg/kg body weight per day SeNPs for 21 days; group III (FA): 100 mg/kg body weight per day FA for 21 days; group IV (AC): 50 mg/kg body weight per day acrylamide for 21 days; group V (AC+SeNPs): AC 50 mg/kg body weight for 21 days then SeNPs as group II. Group VI (AC+ FA): AC 50 mg/kg body weight per day then FA as group III. Results: AC significantly (P<0.05) increased the level of β-amyloid (Aβ) in brain tissue and interleukin 6 (IL6) in serum and significantly (P<0.05) decreased the level of Brain-Derived Neurotrophic factor (BDNF) in the brain tissue compared to control group. Treatment with FA or SeNPs significantly (P<0.05) decreased the level of Aβ in brain tissue and IL - 6 in serum and significantly (P<0.05) increased the level of BNDF in brain tissue compared to acrylamide group. AC induced histopathological changes in brain hippocampus and striatum which were improved with SeNPs and FA treatment. Conclusion: It is concluded from the present study that ferulic acid and SeNPs had a therapeutic effect against neurotoxicity induced by AC in experimental rats.