Abstract

Objective: The aim of this work was to evaluate serum visfatin, ferritin, and lipids as predictors of cardiovascular diseases (CVD) in end-stage renal disease (ESRD) patients. Methods: A controlled trial involving thirty ESRD patients on maintenance haemodialysis (HD); serum was assayed for urea, creatinine, glucose, lipid profile, ferritin and visfatin. Results: patients aged (57.67±5.59 years); 11(36.6 %) were diabetics and 19(63.3%) non-diabetics; 14(46.7%) men and 16(53.3%) women with mean duration of therapy (5.45±2.9 years). Patients have high serum urea, creatinine, non-HDL, TG, LDL-c, VLDL, visfatin, and ferritin (P<0.001) and the calculated risk ratios were high (P<0.001) (VLDL/ HDL, non HDL/HDL, cholesterol/HDL, LDL/HDL, TG/HDL). BMI (P=0.006), weight (P=0.016), HDL-c (P=0.009), glucose (P=0.001, HbA1c (P=0.014) and LDL/VLDL (P=0.045). Visfatin correlated with; BMI (r=0.82, P<0.001), both cholesterol and non-HDL (r=0.98, P<0.001), VLDL/HDL (r=0.49, P=0.006), non HDL/HDL (r=0. 86, P<0.001), cholesterol/HDL (r=0.85, P<0.001), LDL/HDL (r=0.51, P=0.004), TG/HDL (r=0.47, P=0.009) and inversely correlation with HDL-c (r= -0.85, P<0.001). Ferritin; showed inverse correlation with diastolic BP (r=-0.559, P=0.001). Multiple linear stepwise regression analysis confirmed three ratios to be significantly contributing to the risk of CVD in ESRD-HD patients (total cholesterol/HDL, LDL/HDL, and TG/HDL); while VLDL/HDL, not a risk factor. Logistic regression revealed that the risk of CVD is associated with BMI, TG, non-HDL, LDLC, VLDL, urea, glucose, HbA1c and ferritin. Conclusion: Dyslipidemia, hyper-visfatinaemia, and hyper-ferritinemia were prevalent in the ESRD-HD patient's all of which are inde pendent risk factors for CVD; using atherogenic risk ratios as a screening tool for the estimation of CVD risk is useful in those patients